To me S2000 is a special car, purposely engineering FR with 50:50 weight distribution in order to experiment the handling of modern 50:50 high performance sports car.
MR-S is one end product, engineered with the handling data collected from Mk1 and Mk2.
MiTo is an easy handling, little fun driving car with Alfa spirit.
If I were in position to choose, I will take S2000 or MR-S.